It is known to be a ligand of CD47 that, once bound, causes the inhibition of phagocytosis [42] These EV-SIRPαs used red blood cells as delivery vehicles to tumors, effectively inhibiting ligation of residual CD47 molecules and inducing tumor-specific T-cell-mediated antitumor effects, without inducing apparent anemia [40,41]. This evidence concerns the gene CD47 and anemia (phenotype).