Many studies have reported that blocking experiments involving the coinjection or preinjection of unlabeled anti-PD-L1-mAb in excess (3–100-folds) with the tracer protein during 89Zr-iPET scans may enhance tumor imaging characteristics and reduce tracer uptake in PD-L1-expressing nontarget organs and tissues, such as the spleen and lymph nodes [49,56,62,63,67,68]. The gene discussed is CD274; the disease is neoplasm.