For NFs to progress to ANNUBPs, CD16a expression may be required for Schwann cells to infiltrate and proliferate into the surrounding tissues; however, we predict that MPNST cells can independently invade non-neoplastic tissues without CD16a and that the CD16a expression in the ANNUBPs might be associated with neuro-inflammatory proliferative processes. This evidence concerns the gene FCGR3A and malignant peripheral nerve sheath tumor.