NPC1 and Hand-foot syndrome: To characterize proteins identified in blood-circulating NPCs, a bioinformatics analysis was performed using InterPro and InterProScan databases of versions 5.15-58 and 5.15-54,24,25, allowing us to identify the GO categories for NPC proteins from HFs (Supplementary Table S3) and BCPs (Supplementary Table S4) (isoforms not shown).