The combination of SPG7, ADRB1, SMCO4, PHF1, and PSMG1 NPC proteins (Table 4) allows for the differentiation of untreated BCPs in the initial stages of disease (T1N0M0) from HFs with a sensitivity of 100% and a specificity of 80% (Figure 6), while the reduction of the diagnostic panel for the proteomic marker SMCO4 leads to a decrease in the sensitivity to 89% while maintaining the specificity of 80%. This evidence concerns the gene SPG7 and Hand-foot syndrome.