Glucose homeostasis was more prominently affected in the normal weight unhealthy versus the healthy group (higher glucose, insulin and HOMA-IR in MUN), while within the group with obesity the deregulation influenced both glucose (higher insulin and HOMA-IR in MUO) and lipid (lower HDL and higher TRG in MUO) metabolism. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.