IL22 and hepatocellular carcinoma: Recently, Zhang et al., using Th22 cells from healthy donors, and Shi et al., using Th22 cells from patients with CHB, atypical hyperplasia of the liver and HCC, demonstrated that the up-regulation of IL-22 in HBV infection is related to HCC progression [65,66], while Schwarzkopf et al., revealed that high IL-22 serum levels are associated with ACLF and mortality of cirrhotic patients [67].