AFP and hepatocellular carcinoma: A decision to expand from the Milan criteria to the up-to-seven criteria (i.e., the sum of the number of HCC nodules and the diameter of the large nodules in cm less or equal than seven) [14] was reached, with some restrictions related to serum alpha-fetoprotein (AFP) as follows: serum AFP had to be <400 ng/mL at baseline or decreasing of serum AFP below this threshold after successful local ablation therapy had to be proved [6].