APP and Alzheimer disease: Selenium nanoparticles functionalized with Resveratrol (RSV is a natural polyphenolic phytoalexin, found in many plants, including peanuts, eucalyptus, blueberries, cranberries, and grapes, can have antioxidant, anti-inflammatory, neurodegenerative, and neuroprotective effects, neutralizing amyloid beta peptide aggregation and its oxidative effects) maximize the RSV therapeutic potential against Alzheimer’s disease not only due to their antioxidant but also anti-inflammatory action, improving neurocognitive function and modulating signaling pathways [282].