Studies have reported that haploinsufficiency of the FSHR gene (FSHR−/−) could impair follicular formation and development to cause infertility in female mice, and FSHR+/− female mice exhibited increasing levels of serum FSH and LH, and the decreasing levels of serum E2, caused premature exhaustion of the gonadal reserve and progressive decline in reproductive capacity [28,29]. This evidence concerns the gene FSHR and Infertility.