CHEK2 and neoplasm: Other potential protein targets for AV25R that are previously described for their role in tumor progression include Serine/threonine-protein kinase Chk2 (CHEK2), Epidermal growth factor receptor (EGFR), Tyrosine-protein kinase JAK2 (JAK2), Protein-tyrosine kinase 2-beta (PTK2B), TGF-beta receptor type-1 (TGFBR1) and E3 ubiquitin-protein ligase Mdm2 (MDM2).