Although AChE inhibition may be of great interest in studies of the treatment or slowing of Alzheimer’s disease and other neurodegenerative diseases, and cholinesterase activity could be attributed to the main compounds, it seems more reasonable to attribute the anticholinesterase activity of E. valvata EO to an undefined interaction of the enzyme with different components of the oil, and synergistic and antagonistic relationships should be considered. The gene discussed is ACHE; the disease is Alzheimer disease.