APP and Alzheimer disease: In a study using APP/PS1 transgenic mice as a model for Alzheimer’s disease, oral administration of W. somnifera semi-purified extract for 30 days reversed the phenotypes of Alzheimer’s disease such as behavioral impairments, plaque development, and the buildup of beta-amyloid peptides (Aβ) and oligomers in the brains of middle-aged and elderly APP/PS1 transgenic mice [47].