KEAP1 and Familial prostate cancer: It is worth mentioning that the NRF2/KEAP1 signaling pathway plays a key role in neurodegenerative diseases [53], inflammatory therapies [54], as well as in a variety of cancerous and non-cancerous diseases, such as pre-eclampsia [55], ovarian cancer [56], breast cancer [57], prostate cancer [58], and traumatic brain injury [59].