NFKB1 and Alzheimer disease: Our results in this experimental cell model of early-stage AD suggest that a spice blend composed of cinnamon, curcumin, and turmeric (CCSB) can significantly alleviate the damage induced by the Aβ fragment in THP-1 cells via the reduction of ROS, hindering both MAPKs and NF-κB activation, and subsequently decreasing pro-inflammatory cytokine levels (Figure 8).