The typical triggers in IgE-mediated anaphylaxis are food; airborne allergens such as pollen, animal dander, aerosolized foods; latex; medications (oral or parenteral), food-dependent exercise-induced anaphylaxis; allergy to mammalian sugars such as galactose-1,3-alpha-galactose (alpha-gal); seminal fluid and hormones, radiocontrast media reactions [29,30], venom, and anesthetic drugs [31]. The gene discussed is IGHE; the disease is allergic disease.