Familial melanoma represents a relatively commonly encountered entity in the global nosological context of melanoma, being situated in direct relationship with cyclin-dependent kinase inhibitor 2A (CDKN2A) and cyclin-dependent kinase 4 (CDK4), two genes essentially involved in cellular division, whose potential alterations increase the risk of occurrence of melanocytic malignancies [2]. Here, CDK4 is linked to melanoma.