The supposition according to which only certain types of TILs harbor a prognostic value in melanoma patients was supported by the fact that CD8-positive T cells play an essential role in tumor suppression, not only in the context of melanoma, but also in other malignant conditions, such as triple-negative breast cancer [21], advanced gastric cancer [22], and stage II-III colorectal cancer [23]. This evidence concerns the gene CD8A and melanoma.