PHB2 and tuberculosis: Additionally, PHB1 flocks together with PHB2 at the inner mitochondrial membrane to smoothen the mitochondrial functions, such as mitophagy, oxidative phosphorylation, apoptosis, etc. The differential countenance of PHB1 together with cytochrome c oxidase, stomatin-like protein, and cytochrome b-c1 complex pointed to a link between epigenetic distortion and mitochondria functionalities in the great white plague disease or tuberculosis.