IFNG and infection: Control and elimination of Mtb infection has been associated with Th1 response, so expression of IFN-γ, TNF and IL-12 is crucial during early infection for Mtb containment, especially granuloma formation, by which TNF up-regulation is not only necessary for cytokine expression and cell recruitment, but also for maintenance of the structures that prevent replication, containment and could also lead to Mtb elimination [3].