AFP and obesity due to melanocortin 4 receptor deficiency: When adjusting for various possible confounders (age, gender, levels of AFP, ALT, or GGT, diabetes, NAFLD, obesity, smoking status, essential hypertension, or history of ischemic cardiac disease), no significant changes in the AUROC values were achieved for the FIB-4 and APRI scores in predicting the risk of developing cirrhosis (Supplementary Figures S1 and S2, and Supplementary Table S3).