After adjusting the baseline characteristics for possible confounders, like age, gender, the presence of diabetes, NAFLD, obesity, smoking status, essential hypertension, or history of ischemic cardiac disease at baseline, only high AFP and PLT levels in the CHB group, and age and low albumin in the CHD group remained independent predictors for HCC. Here, AFP is linked to obesity due to melanocortin 4 receptor deficiency.