IL6 and brain inflammatory disease: While our previous studies have demonstrated psilocybin and eugenol have synergistic effects on COX-2 and IL-6 within HSIEC in vitro [12], as well as synergistic effects on reducing COX-2 and IL-6 levels within the LPS-induced murine brain inflammation [22], in this study, we only saw synergistic effects at the highest dose of psilocybin (40 μM) combined with eugenol (25 μM) (Table 1).