LEP and type 2 diabetes mellitus: White adipose tissue and visceral adipose tissue play an important role in the inflammatory process in T2D patients as they produce proinflammatory cytokines, such as TNFα, IL-1 and IL-6; hormones such as leptin and adiponectin; and macrophage infiltration, which promotes local and chronic subclinical inflammation leading to T2D and cardiovascular disease [46].