In the case of PCa, it has been shown that exosomal miR-27a can induce resistance to cisplatin, docetaxel, and doxorubicin in recipient cells by degrading p53 mRNA, resulting in reduced expression of the negative regulator of the PI3k/Akt signaling pathway, PTEN (Phosphatase and Tensin Homolog). This evidence concerns the gene PTEN and posterior cortical atrophy.