It has been shown that streptozotocin-induced hyperinsulinemia, hyperglycemia, and cognitive impairment are accompanied by decreased expression of CREB and the anti-inflammatory cytokine IL-10, whereas secretion of the proinflammatory cytokine TNF-α was found to be increased [181,182,183,184]. The gene discussed is CREB1; the disease is Hyperglycemia.