In streptozotocin-induced and db/db diabetic mice, hyperglycemia promotes direct binding of RAGE to mitogen-activated protein kinase kinase 3 (MKK3) and initiates assembly of the MEKK3-MKK3-p38 signaling module, which subsequently accelerates activation of the p38/NF-κB pathway. The gene discussed is NFKB1; the disease is Hyperglycemia.