Studies have shown that the glucomannan fraction of D. officinale attenuates intestinal damage in colitis mice and regulates intestinal mucosal immunity [16]; in cell studies, it is regulated through the toll-like receptor 4/nuclear factor kappa-light-chain-enhancer of activated B cell (TLR4/NF-kB) signaling pathways in gastric epithelial cells (GES-1) [17]. Here, TLR4 is linked to colitis.