Al-Asmari et al. (2016) [38] and Kampo et al. (2019) [39] documented that the venoms from Leiurus quinquestriatus Hemprich & Ehrenberg and Buthus martensi Karch scorpions, respectively, have an immunomodulatory effect on inflammatory mediators such as NF-κB, TNF-α and IL-6; while He et al. (2021) reported that in vitro activation of TNF-α induces invasive and malignant behavior in breast tumor cells [40]. This evidence concerns the gene TNF and breast neoplasm.