TNF and metastatic malignant neoplasm in the lymph nodes: Another aim of this study was the comparison between pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α), inflammatory markers (ESR, fibrinogen, and CRP), and tumor marker (CEA and CA 19.9) levels in CRC patients, alongside their correlation with the tumor characteristics (tumor extension, differentiation grade, lymph node metastasis, and distal metastasis) and the different categories of patients with this type of cancer (depending on age, gender, and lifestyle), to observe which one could be a useful biomarker in the early detection and improved prognosis of this disease.