The Met66Met and Val66Met polymorphisms lead to impairments in intracellular trafficking and regulate secretion in neurons [64], reducing activity-dependent secretion and BDNF intracellular distribution by impairing BDNF intracellular trafficking [65], which impairs neuroplasticity, and thus, the recovery of neurological damage in patients with stroke, leading to worse outcomes [53]. The gene discussed is BDNF; the disease is Stroke.