However, the significant number of studies reported on the association between BDNF and cardiovascular disease and the large heterogeneity of these studies due to specific contexts (e.g., ethnicity), designs (e.g., time of BDNF measurement detection), and patient characteristics (e.g., age or CVD severity) prevent the current literature from providing an overview that would enable weighting of the precise role of BDNF in the context of cardiovascular disease prevention and treatment and directing scientific research toward more standardized studies. This evidence concerns the gene BDNF and cardiovascular disorder.