BDNF and ischemic stroke: Ashcroft et al. (2022), who included 17 studies (6 RCTs, 1 pseudorandomized trial, and 10 nonrandomized studies) to determine the intensity and duration of exercise required to increase BDNF concentrations after stroke, reported a lower risk of ischemic stroke for the GG genotype in both homozygous and dominant models, as shown in the results of impaired BDNF secretion for the A allele (met-BDNF).