We investigated oxidative stress by assessing lipid peroxidation and oxidative damage as indicated by 8-iso-PGF2α and biomarkers of inflammatory status with the measurement of the serum levels of TNF-α, IL-6, IL-10, hs-CRP, and PTX3 in preeclampsia during pregnancy and three months after delivery, in a group of newly diagnosed and untreated pregnant women with PE. The gene discussed is PTX3; the disease is preeclampsia.