Lazuardi et al. [52] analyzed the effects of age on T and B lymphocytes in human lymph nodes from young patients (mean age 11 years, range 1–20) in whom lymphadenectomy was performed for the routine diagnosis of cervical or axillar lymphadenopathy and elderly individuals (mean age 75 years, range 67–88) who underwent pelvic or cervical vascular reconstruction and reported that the relative number of CD8+ T cells decreases with age in human lymph nodes but the relative number of CD4+ T cells does not. Here, CD4 is linked to Lymphadenopathy.