CD274 and familial pancreatic carcinoma: Some new works have revealed good results by combining chemotherapy and sonodynamic therapy for the treatment of pancreatic tumours [58,86,87], while Nesbitt H et al. demonstrated that, when SDT was combined with anti-PD-L1 immune checkpoint inhibition in a murine model of pancreatic cancer, it induced a significant decrease in tumour volume when compared to treatment with SDT only [88].