Keel et al. reported that 13.6% of 110 children and young adults (<40 years old) with MDS had a germline predisposition, with germline variants in FANCA, MPL, RTEL4, SBDS, TERT, TINF2, GATA2, RUNX1, and TP53 [13]. The gene discussed is TINF2; the disease is myelodysplastic syndrome.