CD274 and hypothyroidism: Based on a systematic review, the incidence of hypothyroidism is 8.0–8.5% with anti-PD-1 antibody alone and 4.7–6.0% with anti-PD-L1 antibody alone, and the incidence of hyperthyroidism (toxicosis) is 2.8–3.7% with anti-PD-1 antibody alone and 2.3% with anti-PD-L1 antibody alone [19].