In one more study [24] on 100 Pan-NETs evaluable for ORR and PFS, 57 were non-functioning tumors and 43 cases were associated to an hormonal syndrome (gastrinoma in 14 cases, glucagonoma in 8, insulinoma in 6, VIPoma and PTHrp-producing in 3 each, and serotonin-producing in the remaining 2 patients). This evidence concerns the gene PTHLH and pancreatic insulinoma.