P2RY12 and Stroke: The analysis included 19 studies with a total of 73,126 patients and concluded that aspirin is associated with a higher risk of developing MI (risk ratio, 1.32; 95% CI 1.08–1.62) compared to a P2Y12 inhibitor and a trend to higher risk of bleeding (risk ratio, 1.12; 95% CI 0.82–1.53) and stroke (risk ratio, 1.30; 95% CI 0.89–1.90) [49].