SMART-CHOICE trial, a non-inferiority trial, showed that a short DAPT followed by P2Y12 inhibitors (clopidogrel, prasugrel, or ticagrelor) was non-inferior to standard DAPT therapy for a composite of all-cause death, MI, or stroke (primary end point) compared to 12 months of DAPT (risk difference, 0.4%; 1-sided 95% CI, –∞%–1.3%; p = 0.007 for noninferiority). The gene discussed is P2RY12; the disease is Stroke.