SERPINE1 and cancer: We found that the most significantly enriched signaling pathways in gastric cancer samples with high SERPINE1 expression according to the normalized enrichment score (NES) were pathways related to cancer, specifically, the EPITHELIAL_MESENCHYMAL_TRANSITION, TNFA_SIGNALING_VIA_NFKB, INFLAMMATORY_RESPONSE, KRAS_SIGNALING_UP, and ALLOGRAFT_REJECTION (p < 0.05, Figure 5A).