PRB2 and autoimmune polyendocrinopathy: Similarly, Radin et al. performed TGA in 108 patients with LA positivity and concomitant positivity of other aPLs and found the most severe findings with LA and TGA tests in patients who were tetrapositive (LA, anti-PS/PT, aβ2GPI, and aCL), and these patients also had significant clinical manifestations of APS [15].