In studies using neuroblastoma and melanoma murine models, the absence of CD200/CD200R signaling (using CD200R- mice) caused TAMCs to upregulate CCL24 and CCL8 levels but downregulate the production of CXCL3, CXCL2, and CCL3 [65]. The gene discussed is CXCL2; the disease is neuroblastoma.