Furthermore, Pilch et al. speculated that TLR7 stimulation can subsequently induce cell-mediated immunity and exert its proinflammatory effects through the production of type 1 IFNs, the polarization of tumor-infiltrating macrophages towards the M1 phenotype, and the release of the inflammatory cytokine IL-6 [114,115,116]. The gene discussed is TLR7; the disease is neoplasm.