Although CCL8 has been known to recruit immune cells during the immune response, studies have reported that tumoral CCL8 expression by TAMCs promotes a TME that favors metastasis of cervical cancer, facilitates the migration/invasion of esophageal squamous cell carcinoma, recruits Tregs to the TME, and augments stem-like features in glioblastoma. The gene discussed is CCL8; the disease is glioblastoma.