In recent decades, several epidemiological studies have definitively shown that high Lp(a) levels are associated with a significant increase not only in the risk of atherosclerosis-related cardiovascular (ASCV) events (namely coronary artery disease (CAD), stroke and peripheral artery disease) [2] but also aortic stenosis [3] and atrial fibrillation [4]. The gene discussed is LPA; the disease is coronary artery disorder.