Furthermore, Bucolo et al. demonstrated that low-dose 0.001% hydrocortisone effectively modulated TNF-α, TRAIL, IL-1β, IL-8, and MMP-9 on the ocular surface both in vitro and in vivo and improved TBUT and Schirmer’s test in a rabbit model of dry eye [23]. This evidence concerns the gene TNF and Keratoconjunctivitis sicca.