As shown in Figure 2, HLA-B*46:01 (OR = 1.76, 95% CI: 1.08–2.89, p = 0.02) and HLA-DPB1*02:02 (OR = 1.86, 95% CI: 1.03–3.34, p = 0.04) were significantly associated with an increased risk of allergy severity. The gene discussed is HLA-B; the disease is allergic disease.