The major strength of the study is the analysis of the LPS, LBP, EndoCAb IgM, EndoCAb IgG and fecal calprotectin in patients with T1D, in comparison to healthy subjects and when stratified according to MS status, which has not been reported previously and allowed us to identify signs of a distinct response to endotoxins in T1D. The gene discussed is CD40LG; the disease is myeloid sarcoma.