In fact, telomere dysfunction in lung pathophysiology is significant because some diseases, such as IPF, can be familial by inheriting mutations on telomerase reverse transcriptase (TERT) or telomerase RNA component (TERC), the regulator of telomere elongation helicase 1 (RTEL1), poly(A)-specific ribonuclease (PARN) implied in maturation, dyskerin (DKC1) implied in trafficking, and TERF1-interacting nuclear factor 2 (TINF2) implied in shelterin function [36,37,38]. The gene discussed is TERT; the disease is idiopathic pulmonary fibrosis.