Certain systemic inflammatory markers, such as C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio, are known to play a prognostic role in various types of cancer following surgery [1,2,3]. The gene discussed is TNF; the disease is cancer.