NPM1 and acute myeloid leukemia: Of 60 evaluable patients with R/R KMT2A-rearranged or NPM1-mutant AML, 18 (30%) achieved a composite complete remission (CRc), with complete cytogenetic remission in 64% of patients with KMT2A-rearranged AML who had clearance of bone marrow blasts [159].