In these animals, we also detected a lower percentage of CD4+ MHC II+ activated T helper lymphocytes compared to the group with normal lymph flow without infection (p < 0.05), a lower percentage of CD8+ MHC II+ activated T cytotoxic lymphocytes compared to animals with limb edema and injected with saline (p < 0.01), and a significantly higher percentage of CD19+ B lymphocytes compared with the group with limb edema administered saline (Figure 2) (p < 0.05). The gene discussed is CD8A; the disease is infection.