Patients with lymphedema exhibit a high concentration of lymphocytes in the peripheral lymph and an increased density of MHC class II presenting cells, Langerhans cells, macrophages, and granulocytes in the skin [15,21], as well as the presence of bacteria in deep tissues, tissue fluid, and lymph, mainly saprophytic staphylococci [16,19,22,23]. Here, HLA-C is linked to lymphedema.