Furthermore, the activation of corticotropin-releasing hormone (CRH)-expressing neurons in the paraventricular nucleus of the hypothalamus (PVH) shifts the preference from a carbohydrate-rich diet to an HFD, and these neurons are involved in the development of HFD-induced obesity [17,18]. The gene discussed is CRH; the disease is obesity due to melanocortin 4 receptor deficiency.