In patients with active IBD, there was a differential protein overexpression of IL-36α, IL-36β, IL-36γ, IL-36Ra, and IL-38 observed in various immune cells, including intestinal epithelial cells, macrophages, CD8+ T cells, and/or dendritic cells (pDCs), when compared with noninflamed controls [207]. The gene discussed is IL36A; the disease is inflammatory bowel disease.