IL4 and inflammatory bowel disease: A study by Jayme et al. has shown that IL-4 evokes major transcriptome changes in human blood monocyte-derived macrophages and that hM(IL4)s promote epithelial wound repair in an in vitro assay, reduce cytokine-induced epithelial barrier defects, and are beneficial in a murine model of acute colitis; the study demonstrated the cells’ pro-healing/anti-inflammatory ability and presents this as proof-of-concept support for M(IL4) immunotherapy for IBD [210].