However, during following weeks the hypertension control worsened as the DOC concentration increased even more (during osilodrostat up-titration to maximum dose of 60 mg)—at week 132 it was 14 253 pmol/L (31.4× ULN)—meaning further antihypertensive and mineralocorticoid receptor blockade treatment intensification was required, which resulted in satisfactory BP control at week 156. Here, NR3C2 is linked to hypertensive disorder.