TNFRSF11B and osteoporosis: Due to the role of osteopotegrin in the bone formation process, numerous polymorphisms of the OPG gene have become the subject of research regarding their impact on BMD (rs2073618, rs3102735) [9], the risk of osteoporosis (rs3102735, rs2073618) [10], and the response to treatment in postmenopausal osteoporosis (rs3102735, rs2073618) [11].