Considering the inhibitory roles of the B7H7 molecule in reducing the function of T cells, its constitutive expression by monocytes, and the enhancement of its expression by monocytes and mature DCs with poly I:C, LPS, and IFN-γ, we assumed that B7H7 expression by monocytes-derived DCs is associated with the inhibition of T cell immunity initiated after DCs presented tumor-associated antigens to T cells (Figure 1). The gene discussed is HHLA2; the disease is neoplasm.